TABLE 1.
Epo-specific prolongation of the G1 phase in cells ectopically expressing GATA-1
| Time of cytokine exposure (h) | % of cells in G0/G1 following cytokine exposurea
|
|||||||
|---|---|---|---|---|---|---|---|---|
| FDCW2ER
|
FDCW2ER-pCEKLF
|
FDCW2ER-pMG1
|
FDCW2ER-pCG1
|
|||||
| IL-3 | Epo | IL-3 | Epo | IL-3 | Epo | IL-3 | Epo | |
| 4 | 76.0 | 75.1 | 84.0 | 78.8 | 80.6 | 79.8 | 81.6 | 72.6 |
| 8 | 73.3 | 73.1 | 68.1 | 75.1 | 82.6 | 88.5 | 85.0 | 80.0 |
| 12 | 28.6 | 27.8 | 17.4 | 26.5 | 11.8 | 41.0 | 27.4 | 53.2 |
| 16 | 34.2 | 29.8 | 51.0 | 39.9 | 50.3 | 25.2 | 34.0 | 38.5 |
a
Percentages represent the average of at least three independent experiments. Boldface is used to emphasize the effect of GATA-1 Epo prolongation of the G1 phase.