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. 2024 Feb 23;223(3):e202401056. doi: 10.1083/jcb.202401056

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© 2024 Fassl and Sicinski

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Figure 1. — PC4 regulates cyclin D1 mRNA stability in HCC cells. PC4 is regulated through a ubiquitination (Ub)/phosphorylation (P) switch. In G1 phase, TRIM28 K68-ubiquitinated PC4 binds and stabilizes cyclin D1 mRNA, leading to increased cyclin D1 protein expression. In M phase, PC4 becomes a target of CK2 phosphorylation. S17-phosphorylated PC4 is unable to bind TRIM28 and hence cannot become ubiquitinated. This reduces cyclin D1 transcript stability, resulting in lower cyclin D1 protein levels. Created with http://BioRender.com.