Table 10.

Estimated p Values and Effect Sizes for Comparisons of Microglial Cell Body Area in Three Brain Regions Among Injury × Time Post-Injury Group Combinations from Generalized Linear Mixed Models With Negative-Binomial Error Distributions

Comparison	Hippocampus		Hypothalamus		Motor cortex
	p value	Effect size	p value	Effect size	p value	Effect size
Sham 1 DPI vs. TBI 1 DPI	0.14	0.20	0.27	0.14	<0.001	0.30
Sham 1 DPI vs. sham 7 DPI	0.87	0.08	0.72	0.10	0.99	0.02
Sham 1 DPI vs. sham 25 DPI	0.77	0.10	0.92	0.06	0.99	0.02
TBI 1 DPI vs. TBI 7 DPI	<0.001	0.29	0.05	0.18	<0.001	0.26
TBI 1 DPI vs. TBI 25 DPI	<0.001	0.35	0.004	0.23	0.02	0.22
Sham 7 DPI vs. TBI 7 DPI	0.99	0.03	0.94	0.06	0.94	0.06
Sham 7 DPI vs. sham 25 DPI	0.99	0.10	0.99	0.03	0.98	0.05
TBI 7 DPI vs. TBI 25 DPI	0.97	0.05	0.93	0.06	0.99	0.04
Sham 25 TBI vs. TBI 25 DPI	0.93	0.7	0.99	0.03	0.95	0.06

Statistical significance was achieved if p < 0.05, whereas biological significance was achieved if effect size >0.20. Bold values denote biologically important effects.

DPI, days post-injury; TBI, traumatic brain injury.