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. 2024 Feb 23;9:14. doi: 10.1038/s41525-024-00401-3

Fig. 6. Small cell neuroendocrine prostate cancers express unique prostate-enriched lncRNAs.

Fig. 6

a Differential expression analysis of lncRNAs in adenocarcinomas vs. small cell neuroendocrine (SCNC) carcinomas in scRNA-seq16. b Heatmap for expression of SCNC-lncRNAs in SCNC cells. c Hallmark MSigDB Pathways associated with adeno- and SCNC-lncRNAs in scRNA-seq. d Methylation for HMRs near SCNC-lncRNAs and adeno-lncRNAs in n = 5 SCNC vs. n = 95 adenocarcinoma samples with paired T test P value above14. e Correlation of ref. 19 and single-cell-derived SCNC/adeno-lncRNA signatures with neuroendocrine markers from ref. 43. f ROC curve analysis of ref. 19 and single-cell-derived SCNC/adeno-lncRNA signatures for tumor histology in n = 71 adenocarcinoma and n = 3 NEPC bulk RNA-seq samples. AUC values are given on the right-hand side.