Fig. 5. The regulatory effect of PD-L1-Fc versus PD-L1-Fc/Oxi-αCD nanoparticles on the frequency of inflammatory cells derived from colonic tissues of mice with acute colitis.
Five days post-DSS administration, the frequencies of dendritic (A), macrophage (B), neutrophil (C), Treg (D), Th1 (E), and Tfh (F) cells in isolated colonic lamina propria (LP) cells from the indicated groups were determined by flow cytometry. In (A), p = 1.70043 × 10−3, 8.99799 × 10−2, 7.42287 × 10−7 and 9.63563 × 10−5. In (B), p = 2.45792 × 10−5, 9.00439 × 10−2, 1.10640 × 10−7 and 1.88860 × 10−4. In (C), p = 1.26559 × 10−3, 3.60459 × 10−2, 1.54738 × 10−6 and 3.98454 × 10−4. In (D), p = 2.99412 × 10−2, 9.93452 × 10−1, 1.86512 × 10−5 and 1.06227 × 10−3. In (E), p = 1.83431 × 10−2, 6.69535 × 10−1, 2.33772 × 10−6 and 8.71996 × 10−5. In (F), p = 1.21551 × 10−4, 1.00000, 1.90017 × 10−8 and 2.10744 × 10−6. All data are presented as mean ± SD (n = 3 mice). P values derived from One-way ANOVA analysis followed by Tukey’s multiple comparisons test. Source data are provided as a Source Data file. NPs nanoparticles.