Fig. 6. The regulatory effect of PD-L1-Fc/Oxi-αCD nanoparticles on the frequency of inflammatory cells in the colonic tissues of mice with chronic colitis.
After three cycles of DSS administration, the frequencies of dendritic (A), macrophage (B), neutrophil (C), Treg (D), Th1 (E), and Tfh (F) cells in isolated colonic lamina propria (LP) cells from the indicated groups were determined by flow cytometry. In (A), p = 1.33243 × 10−3, 1.49082 × 10−2, 2.53180 × 10−6 and 8.45033 × 10−4. In (B), p = 1.35429 × 10−8, 3.15662 × 10−2, 3.34360 × 10−11 and 1.35429 × 10−8. In (C), p = 6.35071 × 10−9, 6.79442 × 10−6, 6.80000 × 10−14 and 2.05430 × 10−11. In (D), p = 1.98386 × 10−2, 7.93715 × 10−1, 5.03937 × 10−3 and 1.94161 × 10−2. In (E), p = 2.21669 × 10−3, 9.98089 × 10−1, 8.78094 × 10−6 and 3.84292 × 10−3. In (F), p = 1.59735 × 10−3, 2.07438 × 10−1, 2.73335 × 10−5 and 1.39921 × 10−2. Data are presented as mean ± SD (n = 3 mice). P values derived from One-way ANOVA analysis followed by Tukey’s multiple comparisons test. Source data are provided as a Source Data file. NPs nanoparticles.