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. 2024 Feb 23;14:4. doi: 10.1038/s41387-024-00261-x

Table 4.

Cox regression of all-cause death in the overall MAFLD patients grouped by PA level.

Variables PA inactive PA active
HR (95% CI) P value HR (95% CI) P value
HEI score 0.992 (0.986–0.997) 0.002 0.999 (0.994–1.004) 0.672
PA level 0.993 (0.986–1.000) 0.043 1.000 (0.999–1.001) 0.948
Male, n (%) 1.220 (1.022–1.455) 0.027 1.125 (0.937–1.352) 0.207
Age (years) 1.063 (1.053–1.073) <0.001 1.070 (1.060–1.080) <0.001
Race, n (%) 1.160 (0.974–1.382) 0.097 1.261 (1.041–1.527) 0.018
Low educational level 1.170 (0.999–1.370) 0.051 1.012 (0.863–1.188) 0.880
Low family income 1.017 (0.861–1.201) 0.848 1.264 (1.026–1.558) 0.028
Overdrink, n (%) 1.426 (1.065–1.910) 0.017 1.253 (0.918–1.709) 0.155
Type 2 diabetes, n (%) 1.222 (1.013–1.475) 0.036 1.069 (0.881–1.297) 0.501
Hypertension, n (%) 1.245 (1.049–1.479) 0.012 1.200 (1.012–1.423) 0.036
BMI (kg/m2) 1.003 (0.988–1.019) 0.685 0.986 (0.968–1.004) 0.123
WHR 5.234 (1.989–13.770) 0.001 3.582 (1.132–11.328) 0.030
HbA1c (%) 1.078 (1.027–1.132) 0.003 1.145 (1.087–1.207) 0.000
Cholesterol (mmol/L) 1.009 (0.943–1.081) 0.788 0.995 (0.931–1.064) 0.890
Triglyceride (mmol/L) 1.065 (1.016–1.117) 0.009 1.018 (0.970–1.067) 0.472
AST (U/L) 1.019 (1.009–1.029) <0.001 1.007 (1.000–1.013) 0.038
ALT (U/L) 0.984 (0.976–0.992) <0.001 0.995 (0.988–1.001) 0.107
eGFR (ml/min/1.73m2) 0.992 (0.987–0.997) 0.003 0.996 (0.990–1.002) 0.177
FIB-4 scores 0.985 (0.801–1.212) 0.888 1.130 (0.991–1.288) 0.067
NFS scores 1.021 (0.933–1.116) 0.657 1.026 (0.938–1.122) 0.582

MAFLD Metabolic (dysfunction-) associated fatty liver disease, HEI healthy Eating Index, BMI body mass index, WHR Waist hip ratio, HbA1c glycosylated hemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase, eGFR estimated glomerular filtration rate; FIB-4 fibrosis 4 index, NFS NAFLD fibrosis score.