Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 19;17:1105–1120. doi: 10.2147/JIR.S444758

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Li et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

YAP/TAZ activity is tightly regulated via Hippo signaling. YAP/TAZ subcellular localization and transcriptional co-activator activity in specific contexts are mainly regulated by phosphorylation events. When core Hippo signaling are activated, YAP/TAZ are phosphorylated and promoted to be degradation in cytoplasmic, whereas an inactive Hippo kinase cascade could result in the transportation of YAP/TAZ from cytoplasm to the nucleus and the nuclear accumulation of YAP/TAZ. YAP/TAZ act as prominent links in the Hippo-YAP/TAZ signaling pathway and integrators of several other signal pathways.