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. 2024 Feb 23;13(3):e7038. doi: 10.1002/cam4.7038

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© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Relationship exploration between Hippo pathway and treatment effect in two external immunotherapy cohorts. Comparison of the proportion of Hippo‐enriched alterations in durable clinical benefit (DCB) and No DCB groups in Hellmann. Cancer Cell. cohort (A) and Rizvi.JCO.cohort (B). The landscape of the four genes belonging to the Hippo pathway in Hellmann. Cancer Cell. cohort (C) and Rizvi.JCO.cohort (D). PFS comparison of Hippo pathway mutant and wild‐type groups in Hellmann. Cancer Cell. cohort (E) and Rizvi.JCO.cohort (F). PFS comparison of TMB high and Hippo mutant group, TMB low and Hippo wild‐type group, and the remaining patients in Gandara.Nat Med.OAK cohort (G) and Rizvi.JCO.cohort (H).