Table 6. Multiple analysis of pneumonitis in chemoradiation combined with ICI.
Characteristics | Pneumonitis grade ≥2 | Pneumonitis grade ≥3 | |||||
---|---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | ||
Median age | 1.062 | 0.985–1.145 | 0.118 | ||||
Stage (III vs. IV) | 2.082 | 0.625–6.934 | 0.232 | ||||
ICI (PD-1 vs. PD-L1) | |||||||
History of chronic lung disease (no vs. yes) | 8.351 | 1.469–47.484 | 0.017 | ||||
Median dose | 0.318 | 0.094–1.081 | 0.318 | 0.293 | 0.61–1.414 | 0.126 | |
V5 | 1.100 | 0.562–2.155 | 0.780 | ||||
V20 | 1.382 | 0.708–2.698 | 0.343 | ||||
V30 | |||||||
PTV | 0.924 | 0.451–1.892 | 0.829 |
ICI, immune checkpoint inhibitor; OR, odds ratio; CI, confidence interval; PD-1, programmed cell death protein-1; PD-L1, programmed death ligand-1; PTV, planned target volume.