Table 3.
Results of the 23 drugs identified with good activity after 120 h drug exposure. Mot Redn—motility reduction; MTT Redn—MTT reduction; nd—not determined; p-value applies to both motility and MTT reductions.
| Drug (Molecular Weight/Bioactivity) | Molecular Structure | Trial 1 | Trial 2 | |||
|---|---|---|---|---|---|---|
| Mot Redn (%) | MTT Redn (%) | p-Value | Mot Redn (%) | MTT Redn (%) | ||
| IMMITICIDE, positive control (501.34/Anthelmintic) |
|
100.00 | 91.09 | <0.0001 | 100.00 | Range 77.19–98.88 |
| ATOVAQUONE (366.85/Antimalarial) |
|
100.00 | 90.10 | <0.0001 | 100.00 | 74.42 |
| BENZETHONIUM CHLORIDE (448.09/Antiinfective) |
|
100.00 | 88.12 | <0.0001 | 100.00 | 71.91 |
| CHLORHEXIDINE DIHYDROCHLORIDE (578.38/Antibacterial) |
|
100.00 | 90.10 | <0.0001 | 100.00 | 100.00 |
| GRAMICIDIN, gramicidin A shown (1882.34/Antibacterial) |
|
100.00 | 76.24 | <0.0001 | 100.00 | 84.27 |
| IODOQUINOL (396.96/Antiamoebic) |
|
100.00 | 80.20 | <0.0001 | 100.00 | 87.64 |
| ISRADIPINE (371.40/Calcium channel blocker) |
|
100.00 | 87.13 | <0.0001 | 100.00 | 78.95 |
| LASALOCID SODIUM (612.79/Antibacterial) |
|
100.00 | 89.11 | <0.0001 | 73.33 | 90.70 |
| LEVAMISOLE HYDROCHLORIDE (240.76/Anthelmintic) |
|
100.00 | 92.08 | <0.0001 | 100.00 | 55.81 |
| LOSARTAN (422.92/Antihypertensive) |
|
100.00 | 88.12 | <0.0001 | 100.00 | 82.56 |
| MELOXICAM SODIUM (373.39/Antiinflammatory) |
|
100.00 | 89.11 | <0.0001 | 100.00 | 47.67 |
| METHYLBENZETHONIUM CHLORIDE (462.12/Antiinfective) |
|
100.00 | 91.09 | <0.0001 | 100.00 | 67.44 |
| MITOXANTRONE HYDROCHLORIDE (517.41/Antineoplastic) |
|
100.00 | 91.09 | <0.0001 | 100.00 | 70.93 |
| NITROFURANTOIN (238.16/Antibacterial) |
|
100.00 | 75.25 | <0.0001 | 100.00 | 92.70 |
| NITROFURAZONE (198.14/Antibacterial) |
|
100.00 | 85.15 | <0.0001 | 100.00 | 95.51 |
| OXYQUINOLINE HEMISULFATE (243.24/Antiinfective) |
|
100.00 | 86.14 | <0.0001 | 100.00 | 91.57 |
| PYRANTEL PAMOATE (594.69/Anthelmintic) |
|
100.00 | 85.15 | <0.0001 | 100.00 | 90.45 |
| RIFAXIMIN (785.90/Antibacterial) |
|
100.00 | 91.09 | <0.0001 | 100.00 | 68.60 |
| CEFACLOR (367.81/Antibacterial) |
|
nd | nd | nd | 100.00 | 96.51 |
| DEQUALINIUM CHLORIDE (527.59/Antiinfective) |
|
nd | nd | nd | 100.00 | 61.40 |
| HEXETIDINE (339.61/Antifungal) |
|
nd | nd | nd | 100.00 | 88.60 |
| HOMIDIUM BROMIDE (394.32/Antiprotozoal) |
|
nd | nd | nd | 100.00 | 81.58 |
| NITROXOLINE (190.16/Antibacterial) |
|
nd | nd | nd | 100.00 | 82.46 |
| PENFLURIDOL (523.98/Antipsychotic) |
|
nd | nd | nd | 100.00 | 64.04 |