K = 1.216 × 103 + 2.100 × 10−3 ALogP − 6.597 × 10−4 AATSC5m − 1.453 × 10−2 MATS5c

+ 6.744 × 10−2 MATS4s + 5.535 × 10−3 GATS5m − 3.136 × 10−2 SCH-6 + 2.516 × 10−2 VCH-5

− 2.316 × 10−2 minHBd + 3.159 × 10−3 minHBint7 − 1.681 × 10−3 nAtomLC + 1.964 × 10−3 nFRing

+ 8.021 × 10−3 nT10HeteroRing + 7.442 × 10−4 RDF40m + 3.947 × 10−6 RDF45m

+ 4.102 × 10−5 RDF85m + 1.163 × 10−5 RDF115e − 9.327 × 10−3 E3m