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. 2024 Jan 26;12(2):129. doi: 10.3390/vaccines12020129

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Scheme of using H5, G7, and 2F4 Fc-fusions in treatment and prophylaxis of SARS-CoV-2 infection in a hamster model. (B) Relative weight dynamics in the prophylaxis and treatment groups following administration of Nb-Fc or control total human IgG. Error bars represent means ± SD. (C) Impact of Nb-Fc on the levels of viral transcripts in hamster lungs (RT-qPCR with RdRp-specific primers). RT-qPCR with E gene-specific primers produced very similar results (not shown). Error bars represent means ± SEM.