Table 1.
Characteristics of the patients at inclusion.
| Overall Population (n = 651) |
Eligible for Prophylactic TDF (n = 220) |
Ineligible for Prophylactic TDF (n = 431) | p-Value | ||||
|---|---|---|---|---|---|---|---|
| Age, years | 29 | (25–33) | 27 | (24–32) | 30 | (26–34) | <0.001 |
| Alcohol consump. | 3 | 0% | 1 | 0% | 2 | 0% | 0.74 |
| Primiparas | 194 | 30% | 75 | 34.09% | 119 | 27.61% | 0.09 |
| Gestational age (WA) | 22 | (20–27) | 22 | (19–25) | 23 | (20–28) | 0.37 |
| Known HBV status | 199 | 31% | 58 | 29% | 141 | 32.71% | 0.10 |
| HBeAg positive | 151 | 23.20% | 151 | 69% | 0 | 0.00% | <0.001 |
| ALT (IU/L) | |||||||
| ≥25 | 233 | 36% | 114 | 55% | 119 | 26.86% | <0.001 |
| ≥40 | 94 | 14% | 94 | 43% | 0 | 0.00% | <0.001 |
| HBV viral load | |||||||
| Median, IQR | 3.35 | (1.95–6.89) | 7.81 | (5.47–8.44) | 2.53 | (1.95–3.76) | <0.001 |
| <3.3 | 322 | 49 | 33 | 15% | 289 | 67% | |
| [3.3; 4.3[ | 83 | 13 | 12 | 5% | 71 | 16% | |
| [4.3; 5.3[ | 38 | 6 | 9 | 4% | 29 | 7% | |
| ≥5.3 | 208 | 32 | 166 | 75% | 42 | 10% | <0.001 |
| APRI score | |||||||
| 1.5 | 14 | 2% | 10 | 2% | 4 | 1% | 0.004 |
| 2.0 | 9 | 1% | 6 | 3% | 3 | 1% | 0.044 |
| TREAT-B score | |||||||
| Median, IQR | 1 | (0–2) | 2 | (2–2) | 0 | (0–1) | <0.001 |
| 0 | 247 | 38% | 0 | 0% | 247 | 57% | |
| 1 | 235 | 36% | 51 | 23% | 184 | 43% | |
| 2 | 132 | 20% | 132 | 60% | 0 | 0% | |
| 3 | 34 | 5% | 34 | 15% | 0 | 0% | |
| 4 | 3 | 0% | 3 | 1% | 0 | 0% | <0.001 |
| Eligibility for LTT | |||||||
| By AASLD | 56 | 9% | 46 | 21% | 10 | 2% | <0.001 |
| By EASL | 75 | 12% | 53 | 24% | 22 | 5% | <0.001 |
Data are presented in n (%) or median (IQR); Abbreviations: AASLD: American Association for the Study of Liver Disease, ALT: Alanine Aminotransferase, APRI: AST to Platelet Ratio Index, BMI: Body Mass Index, Consump: consumption, EASL: European Association for the Study of the Liver, Fam. Hist of liver K: Familial history of liver cancer, HBV: Hepatitis B Virus, TDF: Tenofovir Disoproxil Fumarate; TREAT-B: Treatment Eligibility in Africa for the Hepatitis B Virus; WA: Weeks of Amenorrhea.