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The structure of HIF proteins. The top line represents the functions of different domains. All HIF members contain a bHLH motif and two PAS domains (PAS-A and PAS-B). HIF-1β lacks the oxygen-dependent degradation (ODD), the N-TAD, and the inhibitory domain (ID). HIF-3α isoform exhibits an LZIP implicated in DNA binding and protein–protein interaction and lacks the C-TAD and ID domains. Created in BioRender.
