Figure 1.

Helical structure of dermaseptines and their derivatives. These peptides are represented as a two-dimensional axial projection of an ideal α-helix. (a) Helical structure of the native S4; (b) Helix structure of K₄K₂₀S4; (c) Helical structure of K₄S4(1-16); (d) Helical structure of K₃K₄ B2; (e) Helical structure of the native B2. The figures use the one-letter code for amino acids. The aminoacids are presented with different colors according to their proprieties: (grey: nonpolar residue; blue: positively charged residue; yellow: hydrophobic residue; red: for acidic; pink: for Asn (N); purple: The Thr (T) and Ser (S); the arrow in helical wheels corresponds to the hydrophobic moment μH). Figure built using Heliquest software ComputParams form version 3 [28].