Table 2.
Antimicrobial activities and dose-dependent effects of different dermaseptins and their derivatives.
| Peptides |
CC50
Hep-2 Cells (μg/mL) |
A. baumannii MIC (μg/mL) |
A. baumannii MBC (μg/mL) |
|---|---|---|---|
| S4 | 16.51 | 12.5 | 25 |
| K4S4(1-16) | 68.9 | 6.25 | 12.5 |
| K4K20S4 | 75.71 | 3.125 | 6.25 |
| B2 | 30.4 | 12.5 | 25 |
| K3K4B2 | 61.25 | 6.25 | 12.5 |
| meropenem | ND | 32 | 64 |
CC50: peptide concentration that causes 50% cytotoxicity in HEp-2 cells for dermaseptin S4 and derivatives (μg/mL); ND, not determined; MIC: Minimum Inhibitory Concentration (μg/mL); MBC: Minimal Bactericidal Concentration (μg/mL).