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. 2024 Feb 5;16(2):231. doi: 10.3390/pharmaceutics16020231

Figure 5.

Figure 5

Formation and viability of spheroids after treatment with the nanoparticles. Sizes of MCF-7 (A) and T47-D (B) spheroids after 5 days in culture. Bar = 400 µm. Viability of the MCF-7 (C) and T47-D (D) spheroids after exposure to the drug solution in DMSO or to the nanoparticles with encapsulated piplartine or piplartine + YARA for 72 h. Data are shown as the average ± standard deviation of 12 spheroids in 4 independent experiments. * p < 0.05, ** p < 0.01 compared to the piplartine solution (DMSO) and + p < 0.05, ++ p < 0.01 compared to NP-SILY-PIP.