Table 2.
Neuropathologic features of included subjects
| Characteristics | Overall (n = 504) |
ARTAG | P-value* | ||
|---|---|---|---|---|---|
| No (n = 282) |
Yes (n = 222) |
||||
| Braak NFT stage, n (%) | |||||
| 0 | 12 (2.4) | 9 (3.2) | 3 (1.4) | 0.045 | |
| I-II | 84 (16.8) | 48 (17.1) | 36 (16.3) | ||
| III-IV | 109 (21.8) | 49 (17.5) | 60 (27.1) | ||
| V-VI | 296 (59.1) | 174 (62.1) | 122 (55.2) | ||
| Thal phase, n (%) | |||||
| 0 | 48 (9.5) | 26 (9.2) | 22 (9.9) | 0.54 | |
| 1-2 | 51 (10.1) | 25 (8.9) | 26 (11.7) | ||
| 3 | 51 (10.1) | 26 (9.2) | 25 (11.3) | ||
| 4-5 | 354 (70.2) | 205 (72.7) | 149 (67.1) | ||
| Neuritic plaques, n (%) | |||||
| No | 111 (22.0) | 61 (21.6) | 50 (22.5) | 0.72 | |
| Sparse | 56 (11.1) | 29 (10.3) | 27 (12.2) | ||
| Moderate | 101 (20.1) | 54 (19.1) | 47 (21.2) | ||
| Frequent | 236 (46.8) | 138 (48.9 | 98 (44.1) | ||
| TDP-43 in amygdala, n (%) | |||||
| No | 304 (64.0) | 192 (73) | 112 (52.8) | 6.0 × 10−6 | |
| Yes | 171 (36.0) | 71 (27) | 100 (47.2) | ||
| TDP-43 in hippocampus/EC, n (%) | |||||
| No | 237 (62.4) | 134 (68.7) | 103 (55.7) | 0.011 | |
| Yes | 143 (37.6) | 61 (31.3) | 82 (44.3) | ||
| TDP-43 in neocortex, n (%) | |||||
| No | 390 (94.0) | 211 (97.2) | 179 (90.4) | 0.0037 | |
| Yes | 25 (6.0) | 6 (2.8) | 19 (9.6) | ||
| Lewy bodies, n (%) | |||||
| No | 295 (58.6) | 163 (57.8) | 132 (59.7) | 0.72 | |
| Yes | 208 (41.4) | 119 (42.2) | 89 (40.3) | ||
| Cerebral amyloid angiopathy, n (%) | |||||
| None | 148 (29.4) | 78 (27.7) | 70 (31.5) | 0.28 | |
| Mild | 171 (33.9) | 106 (37.6) | 65 (29.3) | ||
| Moderate | 124 (24.6) | 66 (23.4) | 58 (26.1) | ||
| Severe | 61 (12.1) | 32 (11.3) | 29 (13.1) | ||
| Arteriolosclerosis, n (%) | |||||
| None | 68 (13.5) | 47 (16.7) | 21 (9.5) | 0.0027 | |
| Mild | 201 (40.0) | 123 (43.8) | 78 (35.1) | ||
| Moderate | 163 (32.4) | 79 (28.1) | 84 (37.8) | ||
| Severe | 71 (14.1) | 32 (11.4) | 39 (17.6) | ||
| Infarcts and lacunes, n (%) | |||||
| No | 422 (84.1) | 250 (89) | 172 (77.8) | 8.7 × 10−4 | |
| Yes | 80 (15.9) | 31 (11) | 49 (22.2) | ||
| Microinfarcts, n (%) | |||||
| No | 398 (79.0) | 32 (82.3) | 166 (74.8) | 0.047 | |
| Yes | 106 (21.0) | 50 (17.7) | 56 (25.2) | ||
*
P-value is calculated by Fisher’s exact test
SD = standard deviation; NFT = neurofibrillary tangles