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. 2024 Feb 14;16(2):271. doi: 10.3390/pharmaceutics16020271

Table 10.

Independent variables presented in a relationship with the critical quality attributes with actual and predicted responses obtained from response regression study for the analyzed microemulsions.

Variable Independent Variables Dependent Variables
Oleic
Acid
(%)
Tween 20
(%)
PEG 400
(%)
1 Ds
(Actual)
(nm)
Ds
(Predicted)
(nm)
2 W
(Actual)
(mN/m)
W
(Predicted)
(mN/m)
3 D
(Actual)
(cm2/s)
4 Sqrt(D)
(Actual)
(cm2/s)
Sqrt(D)
(Predicted)
(cm2/s)
Code X1 X2 X3 Y1 actual Y1 predicted Y2 actual Y2 predicted Y3 actual Y3 actual Y3 predicted
ME 1 5 30 10 152.89 156.78 69.56 69.19 2.56·10−5 0.0051 0.0051
ME 2 5 40 10 128.90 131.04 81.69 83.79 2.22·10−5 0.0047 0.0047
ME 3 5 30 20 188.33 181.39 89.05 88.30 1.85·10−5 0.0043 0.0043
ME 4 5 40 20 119.60 125.34 71.98 73.70 2.11·10−5 0.0046 0.0046
ME 5 10 30 10 161.34 153.19 20.22 17.61 2.52·10−6 0.0016 0.0016
ME 6 10 40 10 202.29 209.24 16.09 16.38 5.16·10−6 0.0023 0.0023
ME 7 10 30 20 225.13 222.99 13.50 11.86 2.65·10−6 0.0016 0.0017
ME 8 10 40 20 250.20 248.72 11.84 13.10 1.00·10−5 0.0032 0.0031
ME 9 6.25 35 10 133.57 123.92 52.95 47.56 1.27·10−5 0.0036 0.0036
ME 10 8.75 30 15 144.36 154.01 11.29 16.68 3.43·10−6 0.0019 0.0018

1 Ds represents the mean droplet size, 2 W—mean work of adhesion, 3 D—diffusion coefficient, and 4 Sqrt(D)—diffusion coefficient obtained by applying a square root transformation.