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. 2024 Feb 14;16(2):271. doi: 10.3390/pharmaceutics16020271

Table 14.

Setting parameters according to the findings of the factorial design to implement predictive optimization.

No. Variables Trial 1 Trial 2
Goal Limits Goal Limits
1 Oleic acid 7 % 5.0–10% in range 5–10%
2 Tween 20 maximize 30–40% in range 30–40%
3 PEG 400 in range 10–20% in range 10–20%
4 R1 (nm) minimize 119.6–250 nm minimize 119.6–250 nm
5 R2 (mN/m) 60 mN/m 11.29–89.05 mN/m 60 mN/m 11.29–89.05 mN/m
6 R3 (cm2/s) in range 10−5–2.56·10−5 cm2/s in range 10−5–2.56·10−5 cm2/s