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. 2024 Jan 30;16(2):200. doi: 10.3390/pharmaceutics16020200

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanical fracture force analysis of dissolving microneedles (MNs) in terms of the needle aspect ratio. (A) Needle fracture force of PVA-based MNs as a function of actual needle height with a fixed design base diameter of 300 µm. (B) Needle fracture force of PVA-based MNs as a function of base diameter with a fixed design needle height of 600 µm. (C) Needle fracture force of PVA-based MNs as a function of the aspect ratio (needle height/base diameter). The tests were conducted at a compression speed of 0.5 mm/min using a 5 mm diameter rod. Results are expressed as mean ± SD (n = 3–4).