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. 2024 Jan 25;12(2):122. doi: 10.3390/vaccines12020122

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Vaccination with rBCG PspA-PdT/PspA-PdT produces inflammatory cytokines in the lungs of neonate mice. Lung cells obtained from immunized mice 9 days post-administration of the booster dose were cultured for 48 h with rPspA-PdT. Cytokine levels were quantified by mouse Th1/Th2/Th17 cytometric bead array (CBA). Cytokine levels of IL-6 (A), TNF-α (B), IFN-γ (C), IL-17 (D), and IL-10 (E). (F) Overall visualization of groups receiving prime or prime/boost with rBCG PspA-PdT/rPspA-PdT regarding cytokine production in the lungs. All results are represented by the means± SD. * p values < 0.05 were considered statistically significant.