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. 2024 Feb 1;17(2):194. doi: 10.3390/ph17020194

Figure 3.

Figure 3

Effects of (R)-ketamine [7.5, 15, 30 mg/kg i.p., (R)-KET], (S)-ketamine [7.5, 15 mg/kg i.p., (S)-KET], and vehicle (saline, SAL) on EEG theta power (5–9 Hz) for 23 h following administration shown in 6-h periods during REM sleep. Effects of (R)-ketamine on theta power are shown in the (A) 1st–6th hours, (B) 7th–12th hours, (C) 13th–18th hours, and (D) 19th–23rd hours after administration. Effects of (S)-ketamine on theta power are shown in the (E) 1st–6th hours, (F) 7th–12th hours, (G) 13th–18th hours, and (H) 19th–23rd hours after administration. Significant results are indicated by * (compared with vehicle, p < 0.05). The background colors indicate the passive (yellow—lights on) and the active (grey—lights off) phases. Results are presented as mean ± SEM (n = 6–8 rats per group).