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Bi-directional transport across MDCKII-MDR1 of obtained samples.
| Formulation | Papp AP-BL × 10−7 (cm/s) |
Papp BL-AP × 10−7 (cm/s) |
ER (PappBL/PappAP) |
|---|---|---|---|
| DEX | 0.66 ± 0.05 | 1.87 ± 0.07 | 2.84 |
| DEX-loaded NPs | 0.92 ± 0.03 | 0.85 ± 0.03 | 0.92 |
| Diazepam | 146 ± 10 | 123 ± 9 | 0.84 |
| FD4 | 10 ± 1 | 2.0 ± 0.2 | 0.2 |
