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. 2024 Feb 19;29(4):912. doi: 10.3390/molecules29040912

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LA inhibits LPS-induced reprogramming of microglia glucose metabolism. (A) Effect of 2-DG on LPS-induced NO in BV-2 cell; (B) LA decreased ECAR and increased OCR in BV-2 cells (n = 4); (C) LA reduced glucose uptake in inflammatory microglia, n = 4; (D) LA reduced the mRNA expression of key glycolytic enzymes, n = 6; vs. CON, ^### p < 0.001, ^## p < 0.01, ^# p < 0.05; vs. LPS, * p < 0.05, ** p < 0.01, *** p < 0.001, ^&&& p < 0.001; vs. LPS+2DG, ^$$$ p < 0.001. Mean ± SD, n = 6. Data are presented as the mean ± SD. LA: Levistilide A, LPS: lipopolysaccharide.