Table 2.
Median number of infectious episodes before and after MV130 prophylaxis in children.
| Number of Subjects | Episodes (n) | Median [IQR] per Subject | ||||||
|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | P (Wilcoxon) |
H-L | % Decrease in the Number of Episodes | ||
| Upper Respiratory Infections | 143 | 744 | 151 | 5.0 (4.0, 6.0) | 1.0 (0.0, 2.0) | <0.001 | − 4.0 ( − 4.5, − 4.0) | 80% |
| Tonsillitis | 82 | 419 | 87 | 5.0 (4.0, 6.0) | 1.0 (0.0, 2.0) | <0.001 | −4.0 (−4.5, −4.0) | 79% |
| Pharyngitis | 6 | 43 | 6 | 5.0 (4.3, 5.0) | 1.0 (0.3, 1.0) | 0.027 | −4.0 (−12.5, −2.0) | 86% |
| Pharyngotonsillitis | 20 | 99 | 15 | 4.0 (4.0, 6.0) | 1.0 (0.0, 1.0) | <0.001 | −4.0 (−0.5, −3.0) | 85% |
| Rhinitis/Rhinosinusitis | 6 | 31 | 9 | 5.0 (3.3, 6.0) | 1.5 (1.0, 2.0) | 0.027 | −3.0 (−6.5, −1.5) | 71% |
| Rhinitis/rhinosinusitis/Pharyngotonsillitis | 10 | 52 | 7 | 5.0 (4.3, 5.8) | 1.0 (0.0, 1.0) | 0.005 | −4.5 (−5.0, −4.0) | 87% |
| AOM | 8 | 36 | 12 | 4.5 (4.0, 5.0) | 2.0 (1.0, 2.0) | 0.011 | −3.0 (−4.0, −2.0) | 67% |
| AOM/Pharyngotonsillitis/Rhinosinusitis | 8 | 43 | 10 | 5.0 (4.8, 5.0) | 0.5 (0.0, 2.0) | 0.017 | −4.0 (−6.0, −2.0) | 77% |
| Common cold | 3 | 21 | 5 | 8.0 (6.5, 8.0) | 2.0 (1.5, 2.0) | 0.103 | −5.5 (−6.0, −4.0) | 76% |
| Lower Respiratory Infections | 43 | 221 | 93 | 5.0 (4.0, 6.0) | 2.0 (1.0, 3.0) | <0.001 | − 3.0 ( − 3.5, − 2.5) | 58% |
| Recurrent bronchitis | 41 | 211 | 90 | 5.0 (4.0, 6.0) | 2.0 (1.0, 3.0) | <0.001 | −2.5 (−3.5, −2.0) | 57% |
| Other infections of the lower respiratory tract | 2 | 10 | 3 | 5.0 (4.5, 5.5) | 1.5 (1.3, 1.8) | 0.178 | −3.5 (−4.0, −3.0) | 70% |
| All | 186 | 965 | 244 | 5.0 (4.0, 6.0) | 1.0 (0.0, 2.0) | <0.001 | − 4.0 ( − 4.5, − 2.5) | 75% |
AOM: Acute Otitis Media.