Table 4.
Median number of antibiotic courses before and after MV130 prophylaxis in children.
| Number of Subjects | Antibiotic Courses (n) | Median [IQR] per Subject | ||||||
|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | P (Wilcoxon) |
H-L | % Decrease in the Number of Antibiotic Courses | ||
| Upper Respiratory Infections | 143 | 671 | 115 | 5.0 (4.0, 5.0) | 0.0 (0.0, 1.0) | <0.001 | −3.0 ( −3.5, −3.0) | 83% |
| Tonsillitis | 82 | 393 | 72 | 5.0 (4.0, 5.0) | 0.0 (0.0, 1.0) | <0.001 | −4.0 (−4.5, −3.5) | 82% |
| Pharyngitis | 6 | 41 | 6 | 4.0 (3.3, 4.8) | 1.0 (0.3, 1.0) | 0.043 | −3.0 (−14, −0.5) | 85% |
| Pharyngotonsillitis | 20 | 76 | 6 | 4.0 (3.0, 4.0) | 0.0 (0.0, 1.0) | <0.001 | −3.5 (−4.0, −2.5) | 92% |
| Rhinitis/Rhinosinusitis | 6 | 24 | 5 | 3.0 (3.0, 3.8) | 1.0 (0.3, 1.0) | 0.028 | −2.5 (−5.5, −1.5) | 79% |
| Rhinitis/rhinosinusitis/Pharyngotonsillitis | 10 | 46 | 4 | 5.0 (4.0, 5.0) | 0.0 (0.0, 1.0) | 0.005 | −4.5 (−5.0, −3.5) | 91% |
| AOM | 8 | 36 | 12 | 4.5 (4.0, 5.0) | 2.0 (1.0, 2.0) | 0.012 | −3.0 (−4.0, −2.0) | 67% |
| AOM/Pharyngotonsillitis/Rhinosinusitis | 8 | 46 | 10 | 5.5 (4.8, 6.3) | 0.5 (0.0, 2.0) | 0.018 | −4.5 (−6.5, −2.5) | 78% |
| Common cold | 3 | 9 | 0 | 3.0 (3.0, 3.0) | 0.0 (0.0, 0.0) | 0.109 | −3.0 (−3.0, −3.0) | 100% |
| Lower Respiratory Infections | 43 | 110 | 30 | 2.0 (1.0, 3.5) | 0.0 (0.0, 1.0) | <0.001 | −1.5 ( −2.0, −1.5) | 73% |
| Recurrent bronchitis | 41 | 103 | 27 | 2.0 (1.0, 3.0) | 0.0 (0.0, 1.0) | <0.001 | −1.5 (−2.0, −1.5) | 74% |
| Other infections of the lower respiratory tract | 2 | 7 | 3 | 3.5 (3.3, 3.8) | 1.5 (1.3, 1.8) | 0.180 | −2.0 (−2.0, −2.0) | 57% |
| All | 186 | 781 | 145 | 4.0 (3.0, 5.0) | 0.0 (0.0, 1.0) | <0.001 | −3.5 ( −3.5, −3.0) | 81% |
AOM: Acute Otitis Media.