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. 2024 Feb 11;16(2):281. doi: 10.3390/v16020281

Figure 2.

Figure 2

Volcano plot of the expression of investigated genes. The volcano plot vividly captures the transcriptional dynamics of key genes in fifteen COVID-19 patients who did not use metformin and fifteen COVID-19 patients who did use metformin. Five patients who did not take metformin had a significantly reduced expression of the FOXP3 gene, and two more samples each had a significantly increased expression of RORC and TBX21 (A). In contrast, increased expression of FOXP3 and decreased expression of RORC and TBX21 were observed in patients taking metformin (B).