TABLE 2.

The relationship between common neurological disorders and cholesterol metabolism.

Disease	Experimental model	Experimental aim	Conclusion	References
AD	AD mice	The effect of LXR agonist TO901317 on the cognitive function of AD mice.	TO901317 reduces the production of Aβ in the brain by promoting cholesterol efflux.	123
	AD mice	The effect of increased cholesterol abundance on neurodegeneration.	The increase in cholesterol content in neurons in the brain may help induce and/or worsen AD.	124
		The effect of AD on the ability of ABCA1‐mediated cholesterol efflux.	In AD patients, ability of ABCA1‐mediated cholesterol efflux decreases.	125
		The contribution of ApoE4 and astrocytes to amyloidosis in AD.	ApoE4 astrocytes induce amyloidosis through cholesterol oversupply.	126
PD	PD mice	The relationship between hypercholesterolemia and dopaminergic neurodegeneration.	Hypercholesterolemia can lead to oxidative stress and mitochondrial dysfunction, inducing dopaminergic neurotoxicity.	127
		Levels of cholesterol metabolites in cerebrospinal fluid of PD patients.	7α‐hydroxycholesterol levels are positively correlated with depression in PD patients.	128

Abbreviations: Aβ, amyloid proteins‐β; AD, Alzheimer's disease; PD, Parkinson's disease.