Table 3.

Biological activity predictions for flavokawain B (FB1) and its metabolites (FB2–FB8) using the passOnline tool

Compound	Activity	Membrane integrity agonist	Caspase 3 stimulant	Antiprotozoal (Leishmania)	Free radical scavenger	Hepatoprotectant	Anticarcinogenic	Vasoprotective
FB1	Pa	0.894	0.892	0.765	0.599	0.569	0.476	0.608
	Pi	0.012	0.004	0.006	0.006	0.015	0.022	0.019
FB2	Pa	0.906	0.865	0.759	0.626	0.599	0.507	0.587
	Pi	0.010	0.004	0.006	0.005	0.012	0.019	0.022
FB3	Pa	0.931	0.952	0.947	0.873	0.907	0.881	0.896
	Pi	0.005	0.003	0.002	0.002	0.002	0.003	0.003
FB4	Pa	0.941	0.955	0.948	0.921	0.913	0.897	0.867
	Pi	0.004	0.003	0.002	0.002	0.002	0.003	0.004
FB5	Pa	0.940	0.947	0.948	0.914	0.915	0.895	0.876
	Pi	0.004	0.003	0.002	0.002	0.002	0.003	0.003
FB6	Pa	0.911	0.895	0.768	0.682	0.586	0.530	0.527
	Pi	0.008	0.004	0.006	0.004	0.013	0.017	0.033
FB7	Pa	0.935	0.969	0.950	0.909	0.903	0.888	0.875
	Pi	0.005	0.002	0.002	0.002	0.002	0.003	0.003
FB8	Pa	0.927	0.966	0.957	0.934	0.920	0.904	0.856
	Pi	0.005	0.002	0.002	0.001	0.002	0.002	0.004

Pi stands for likely idleness, and Pa for likely activity. The values range from 0 to 1, with 0 denoting no likelihood of Pa or Pi and 1 denoting 100% probability