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. Author manuscript; available in PMC: 2024 Feb 24.
Published in final edited form as: J Surg Res. 2022 Oct 19;282:118–128. doi: 10.1016/j.jss.2022.09.011

Fig. 2 –

Fig. 2 –

Furin inhibition moderates GPC3 cleavage with minimal reduction in cell growth after single treatment. (A) N-terminal (40 kDa) GPC3 protein expression is reduced in HepG2 cells treated with FI compared to control (C) at four and 6 h with sustained reduction through 48 h after single treatment. No change seen in full-length (70 kDa) or furin protein expression. (B) Furin protein expression in SKHep1 cells had variable response to FI, with no prominent trend. (C) HepG2 cells treated with FI and evaluated at early (2, 4, 6, 8 h) and late (24 and 48 h) time points showed no significant reduction in proliferation. (D) SKHep1 cell proliferation was unchanged after single treatment with FI.