Table 2 ∣.
Inhibitory and stimulatory transcription factors and complexes in regulatory T cells
TFs and TF complexes | Genes regulated |
---|---|
Inhibitory TFs and complexes | |
AHR–FOXP3–Aiolos | IL2, IFNG, IL17A |
BACH2–MAFK | PRMD1, GATA3, NFIL3, JUN–AP-1, IRF4, AHR, GZMB |
FOXP3–RORγt | IL17A |
FOXP3–RUNX1–RELA–p50–NFAT | IL2, IFNG, IL4, RORC, SATB1 |
NFIL3 | FOXP3, IL2RA |
Stimulatory TFs and complexes | |
BATF | IL10, CTLA4, TIGIT, TNFRSF4, TNFRSF9, IL1RL1 |
BCL11B | IL10, FOXP3 |
BLIMP1–BCL-6–NFAT | CXCR5 |
BLIMP1–FOXP3–IRF4 | IL10 |
Ikaros | IL7R, FOXO1 |
FOXP3 | BATF |
FOXP3–RORγt–AHR | IL10, GPR15 |
RORγt | IL17A |
STAT3 | IL17A, RORC |
During regulatory T cell differentiation, transcriptional interactions result in the transient assembly of both inhibitory and stimulatory transcription factors (TFs) and complexes, which independently or in conjunction with FOXP3, repress or induce the expression of genes involved in the maintenance of hallmark regulatory T cell genes and specialized function within tissues.