Figure 4:

Representative risk of major hospital complication is associated with aortic calcium volume and regionality. (A) Variable of importance plot. Variables with larger values are more important to the random forest model in predicting a major hospital complication. Variable acronyms/names are available in Supplementary Material, Table S8. (B) Partial-dependence risk-adjusted graph of association between total calcium score and predicted probabilities of composite major hospital complication (death, stroke, renal failure requiring dialysis). Risk-adjusted estimates are based on random forest classification. Symbols represent ensemble averages (probabilities) across total calcium volume, and solid line depicts smoothing spline curves of these probabilities. AV: aortic valve; BMI: body mass index; Hx: history; NYHA: New York Heart Association Symptom Class; SAVR: surgical aortic valve replacement; TAVR: transcatheter aortic valve replacement.