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. 2024 Feb 24;15:1685. doi: 10.1038/s41467-024-45995-5

Fig. 6. ECM1 in the sEVs plays a role in enhancing BC growth and metastasis.

Fig. 6

a A schematic diagram showing the sEVs treatment protocol. b Protein expressions of ECM1, MMP3 and S100A/B in the tumors of E0771-bearing B6/J-Rab27a-Cas9-KO mice after C-sEVs, D-sEVs or ECM-sEVs treatments. c Tumors, d tumor size, e tumor weight and f lung metastasis of the E0771-bearing B6/J-Rab27a-Cas9-KO mice after sEVs treatments. Mouse tumor sizes are presented as the mean ± SEM, other data are presented as mean ± SD; one-way ANOVA with Tukey’s multiple comparison test for (b, d, e); n = 7 mice in each group, p values are indicated in graphs. Rab27aKO, B6/J-Rab27a-Cas9-KO mice; C-sEVs, circulating sEVs in CD-fed C57BL/6 mice; D-sEVs, circulating sEVs in high-fat-diet induced obesity C57BL/6 mice; ECM-sEVs, ECM1 construct-loaded C-sEVs; ECM1, extracellular matrix protein 1; MMP3, matrix metallopeptidase 3. Source data are provided as a Source Data file.