Table 1.
Differentially expressed proteins (DEPs) in the circulating sEVs
| Overlaping | Mice Accession | Trend | BT: BC | P value | Human Accession | Trend | OB: NC | P value |
|---|---|---|---|---|---|---|---|---|
| PON1 | P52430 | Down | 0.416869 | 0.072844 | P27169 | Up | 1.410720 | 0.026810 |
| SERPING1 | P97290 | Down | 0.679204 | 0.246092 | P05155 | Up | 1.373380 | 0.004385 |
| F13B | Q3UER0 | Down | 0.501187 | 0.000005 | P05160 | Up | 1.584380 | 0.010348 |
| CPN2 | Q9DBB9 | Up | 1.819701 | 0.082274 | P22792 | Up | 1.759430 | 0.026131 |
| APOB | E9Q1Y3 | Down | 0.343558 | 0.000955 | P04114 | Up | 2.001660 | 0.011371 |
| F5 | O88783 | Up | 2.558586 | 0.011448 | P12259 | Up | 1.441020 | 0.042143 |
| PSMA1 | Q3TS44 | Down | 0.549541 | 0.036935 | P25786 | Up | 3.236740 | 0.048003 |
| A2M | Q6GQT1 | Down | 0.564937 | 0.050095 | P01023 | Down | 0.797260 | 0.024444 |
| ITIH4 | E9Q5L2 | Down | 0.549541 | 0.008112 | Q14624 | Up | 1.310230 | 0.034684 |
| CD5L | Q9QWK4 | Down | 0.549541 | 0.020155 | O43866 | Down | 0.671800 | 0.042232 |
| ECM1 | Q3TXB7 | Up | 2.630268 | 0.000273 | Q16610 | Up | 1.357100 | 0.049087 |
| KNG1 | A0A0R4J038 | Up | 5.649370 | 0.021724 | P01042 | Up | 1.673730 | 0.006762 |
| FN1 | A0A087WSN6 | Up | 1.584893 | 0.045708 | P02751 | Up | 1.626480 | 0.001375 |
| PLTP | Q3UFS5 | Down | 0.373250 | 0.122686 | P55058 | Up | 3.696800 | 0.009497 |
| GPLD1 | Q7TNZ4 | Up | 2.269865 | 0.010958 | P80108 | Up | 2.055300 | 0.016015 |
Comparison of the differentially expressed proteins (DEPs) in the circulating sEVs purified from the plasma of the human subjects with obesity or overweight (OB) and normal weight healthy human subjects (NC), and the DEPs of the circulating sEVs purified from the plasma of the control diet-fed mice (BC) and high fat diet-induced obesity mice (BT). Two-sided unpaired t-test are used for statistical analysis.