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. 2024 Feb 24;15:1697. doi: 10.1038/s41467-024-45969-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Average Cas9-independent off-target editing across all cytosines for six orthogonal R-loops (SaR1–SaR6) generated by a dead S. aureus Cas9. Data are presented as mean values ± SD. Dots represent individual values from independent biological replicates. b Off-target RNA editing. Base editors were transfected into HEK293T cells and harvested after 48 hours. cDNA was synthesized, and high-throughput sequencing was used to analyze CTNNB1, IP90, and RSL1D1. Data are presented as mean values ± SD. Dots represent individual values from independent biological replicates. Source data are provided as a Source Data file.