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. 2024 Feb 24;15:1697. doi: 10.1038/s41467-024-45969-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — CBE6 variants were used to install stop codons in PCSK9, a therapeutic strategy for lowering LDL cholesterol levels. The gray boxes indicate the desired location of stop codon installation. Data are presented as mean values ± SD. Dots represent individual values from independent biological replicates. PAM sequences are underlined. Source data are provided as a Source Data file.