Fig. 2. BMP/TGFβ signaling pathways are defective in the decidualizing stromal cells from individuals with endometriosis.

Differentially expressed genes between the endometrial stromal cells of individuals without (n = 4) or with endometriosis (n = 3) at each time point during the decidualization treatment were identified and visualized as volcano plots. Differentially expressed genes were determined using a cut off ( | log2 fold-change | >1 and FDR < 0.05, red denotes increased genes, blue denotes decreased genes, gray indicates no significant change) and displayed following Day 2 (A), Day 4 (B), Day 6 (C), or Day 8 (D) of treatment with the EPC decidualization cocktail (35 nM estradiol, 1 µM medroxyprogesterone acetate, 50 µM cAMP). E Gene ontology analysis of the differentially expressed genes was performed at each time point and visualized as a dot plot. Genes in the TGFβ signaling pathway were identified to be enriched at each of the time points after EPC treatment.