Fig. 6. Ceralasertib improves survival of LUAD GEMM and impacts TIME.
a Kaplan–Meier survival analysis of TB mice treated with vehicle (n = 7) or ceralasertib (cerala) (n = 8) (Day 50 7days on / 7days off + 1day on). b GEMM KrasG12C;p53-/- lung tumors were profiled by flow cytometry for the indicated immune populations. The results of individual mice, median and SD are shown P values were calculated in two-sided unpaired Student’s t-test. N = 9 for vehicle, N = 9 for AZD6738 groups. Non-significant (p > 0.05) p values are not shown. N = 5 for vehicle and N = 4 for ceralasertib groups, c Heatmap of IFNI signature gene expression, calculated from FPKM normalized counts expressed above biological viable levels, log-transformed and normalized for gene lengths. The data was z-transformed to be visualized in heatmap. Source data are provided as a Source Data file.