Fig. 4.
Interaction between the gut mycobiome and host serum and fecal metabolomes. A Explanatory power between different omics datasets. The explanatory power was quantified as adjusted R2 obtained from stepwise PERMANOVA analysis, as detailed in the Methods. Arrows indicated the direction and magnitude of explanatory power, with numbers indicating the corresponding values. B The explanatory power of the gut mycobiome on host serum and fecal metabolomes in ESRD patients and healthy controls. C Heatmap displaying the Spearman's rank correlation coefficients between fungal species and host metabolites. Fungal species enriched in ESRD patients were colored in brown, while those enriched in healthy controls were colored in blue. The q-value was obtained using the Benjamini and Hochberg adjustment. Correlations with a q-value < 0.05 were considered statistically significant