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. 2024 Feb 23;10(1):e003926. doi: 10.1136/rmdopen-2023-003926

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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PRF and GZMB secretion by CD8⁺CCR4⁺ T cells. Sorted CD8⁺CCR4⁺ T cells were stimulated with phorbol 12-myristate 13-acetate and ionomycin for 5 hours and expression of CX3CR1, PRF and GZMB was assessed. (A) Representative plot showing CX3CR1^- (black) and CX3CR1⁺ (red) cells expressing PRF and GZMB. Numbers in each quadrant report percentages relative to the parental population. (B) Mean frequencies±SEM of PRF⁺GZMB⁺ cells relative to CD8⁺CCR4⁺ CX3CR1^- (black) or CX3CR1⁺ (red) cells. Each symbol represents an individual, and Kruskal-Wallis was used to compare PRF and GZMB production between groups within the CX3CR1⁺ or the CX3CR1^- populations. Asterisks indicate significant differences between the groups (*p<0.05, **p<0.01). GZMB, granzyme B; PRF, perforin.