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FAK- PROTAC domain structure and working principle. The FAK-PROTAC system comprises three essential components: a specifically designed warhead to bind to FAK, an E3 ubiquitin ligand responsible for recruiting E3 ubiquitin ligase, and a linker connecting the two. PROTAC functions by facilitating the proximity between FAK and E3 ubiquitin ligase, which subsequently leads to ubiquitination, followed by proteasome degradation. PROTAC: Proteolysis Targeting Chimera.
