FIGURE 1.

Caspase-1 plasma levels were significantly elevated in all ICU patients and were an accurate predictor of sepsis. a) Interleukin (IL)-18 and b) IL-1β were elevated in sepsis patients, an observation consistent with previously published work. c) Plasma caspase-1 levels were elevated in both intensive care unit cohorts, and were highest in the sepsis cohort. d) Receiver operating curve (ROC) analysis using non-sepsis as the control and sepsis as the patient group (area under the curve (AUC) 0.7080). ns: nonsignificant. *: p<0.05 was considered significant when comparing medians using a Steel test.