FIGURE 4.

Aβ isoform Aβx-40 and Aβx-42 plasma levels increased significantly from time of admission to 7 days post-admission (7dp). a) Analyte plasma levels are represented as the fold change from 7 days post­intensive care unit (ICU) admission (7dp) compared to the levels at the time of ICU admission (Admission). CXCL-8 plasma levels were significantly reduced from time of admission to 7dp whereas interleukin (IL)-18, IL-1β, IL-6, IL-10, MCP-1 and caspase-1 plasma levels were unchanged. b) Caspase-1 plasma levels were not significantly reduced from admission to 7dp, but the levels trended towards reduction in both the non-sepsis and sepsis cohorts. a), c) and d) Aβx-40 and Aβx-42 plasma levels were significantly higher at 7dp compared to admission in the sepsis cohort, whereas Aβx-40 plasma levels were also significantly higher in the non-sepsis cohort. ns: nonsignificant. *p<0.05, **p<0.005 and ****p<0.0001 were considered significant using either a) one-sample t-test comparing the means to 1 or b–d) paired t­-test.