Table 5.
Associations between latent class growth analysis three-classes model and substance misuse and employment/educational adverse outcomes at 24 years
| Outcome | OR | 95% CI | P |
|---|---|---|---|
| Substance misuse at 24 years | |||
| DAWBA anxiety | |||
| Anxiety Class1 (ref) | – | – | – |
| Anxiety Class2 | 1.04 | 0.90 to 1.20 | 0.628 |
| Anxiety Class3 | 0.83 | 0.62 to 1.11 | 0.210 |
| Gender | 2.51 | 2.20 to 2.86 | <0.001 |
| Gestational age | 1.02 | 0.99 to 1.06 | 0.161 |
| FAI total score | 1.03 | 1.02 to 1.05 | <0.001 |
| Ethnicity | 0.99 | 0.64 to 1.55 | 0.977 |
| Maternal age birth | 0.99 | 0.98 to 1.01 | 0.194 |
| DAWBA depression | |||
| Mood Class2 (ref) | – | – | – |
| Mood Class1 | 1.44 | 1.18 to 1.86 | 0.031 |
| Mood Class3 | 1.32 | 0.99 to 1.92 | 0.071 |
| Gender | 2.41 | 2.12 to 2.75 | <0.001 |
| Gestational age | 1.03 | 0.99 to 1.07 | 0.084 |
| FAI total score | 1.02 | 1.01 to 1.03 | 0.003 |
| Ethnicity | 1.01 | 0.65 to 1.56 | 0.908 |
| Maternal age birth | 0.99 | 0.98 to 1.01 | 0.480 |
| DAWBA anxiety + depression | |||
| A + D Class2 (ref) | – | – | – |
| A + D Class1 | 1.51 | 1.25 to 1.82 | 0.005 |
| A + D Class3 | 1.57 | 1.15 to 2.15 | <0.001 |
| Gender | 2.36 | 2.08 to 2.68 | <0.001 |
| Gestational age | 1.03 | 0.99 to 1.07 | 0.057 |
| FAI total score | 1.02 | 1.01 to 1.03 | <0.001 |
| Ethnicity | 1.00 | 0.64 to 1.55 | 1.00 |
| Maternal age birth | 1.00 | 0.99 to 1.02 | 0.719 |
| Any education/employment problem at 24 years | |||
| DAWBA anxiety | |||
| Anxiety Class1 (ref) | – | – | – |
| Anxiety Class2 | 1.27 | 1.10 to 1.47 | 0.001 |
| Anxiety Class3 | 1.56 | 1.20 to 2.03 | 0.001 |
| Gender | 0.89 | 0.78 to 1.01 | 0.083 |
| Gestational age | 0.94 | 0.91 to 0.98 | 0.001 |
| FAI total score | 1.03 | 1.02 to 1.04 | <0.001 |
| Ethnicity | 0.92 | 0.57 to 1.50 | 0.747 |
| Maternal age birth | 1.10 | 0.99 to 1.12 | 0.207 |
| DAWBA depression | |||
| Mood Class2 (ref) | – | – | – |
| Mood Class1 | 1.77 | 1.47 to 2.12 | <0.001 |
| Mood Class3 | 1.38 | 1.00 to 1.91 | 0.047 |
| Gender | 0.86 | 0.76 to 0.98 | 0.026 |
| Gestational age | 0.94 | 0.91 to 0.98 | 0.001 |
| FAI total score | 1.03 | 1.01 to 1.04 | <0.001 |
| Ethnicity | 1.04 | 0.66 to 1.65 | 0.854 |
| Maternal age birth | 1.01 | 0.99 to 1.03 | 0.114 |
| DAWBA anxiety + depression | |||
| A + D Class2 (ref) | – | – | – |
| A + D Class1 | 1.68 | 1.40 to 2.01 | <0.001 |
| A + D Class3 | 1.48 | 1.07 to 2.05 | 0.018 |
| Gender | 0.86 | 0.76 to 0.98 | 0.022 |
| Gestational age | 0.96 | 0.92 to 0.99 | 0.009 |
| FAI total score | 1.03 | 1.02 to 1.04 | <0.001 |
| Ethnicity | 1.02 | 0.64 to 1.62 | 0.926 |
| Maternal age birth | 1.01 | 0.99 to 1.02 | 0.198 |
Significance level at <0.050 (bold). A + D, DAWBA Generalised anxiety composite score + DAWBA mood total score (i.e. internalising symptoms); FAI, Family adversity index.