Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reagents and conditions: (i) MeI, K2CO3, DMF, 60 °C, 1 h, 23% for 8 and 26% for 12; (ii) 7 M NH3 in MeOH, RT, 16 h; (iii) 10% Pd/C, H2 (g), EtOH, 60 °C, 16 h, two-step yield 92% for 10 and 96% for 14; (iv) 4-fluorobenzoic acid, TEA, PyBrop, DCE, MW 120 °C, 20 min; (v) KOtBu, iPrOH, MW 130 °C, 30 min, two-step yield 73% for 11 and 76% for 15.
