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Reagents and conditions: (i) ethyl 2-diazoacetate, NaOEt, toluene 0 °C to RT, 18 h, 20%; (ii) 4-fluorobenzoic acid, TEA, PyBrop, DCE, MW 120 °C, 30 min; (iii) 7 M NH3 in MeOH, MW 100 °C, 3 d; (iv) KOtBu, iPrOH, MW 130 °C, 85 min, 17% over four steps.
