Table 3. In Vitro Antitrypanosomal Activity and Cytotoxicity of R4 Analogues.
| compound | R4 | MW | cLogPa | tPSAa | pIC50b |
|
|---|---|---|---|---|---|---|
| T. brucei | MRC-5 | |||||
| 31f | H | 230.2 | 2.0 | 70.1 | <4.2 | <4.2 |
| 31e | Me | 244.2 | 2.2 | 70.1 | 4.6 ± 0.4 | <4.2 |
| 31d | Et | 258.3 | 2.7 | 70.1 | 6.4 ± 0.0 | <4.2 |
| 2 | iPr | 272.3 | 3.1 | 70.1 | 7.2 ± 0.2 | <4.2 |
| 31c | tBu | 286.3 | 3.4 | 70.1 | 7.8 ± 0.3 | <4.2 |
| 31a | cyclopentyl | 298.3 | 3.5 | 70.1 | 8.0 ± 0.0 | <4.2 |
| 31b | cyclohexyl | 312.3 | 3.9 | 70.1 | 7.4 ± 0.0 | <4.2 |
| 35 | Ph | 306.3 | 3.6 | 70.1 | 7.3 ± 0.1 | <4.2 |
a
cLogP and tPSA are adopted from the CDD Vault.
b
Mean values ± standard deviations, n ≥ 2.