Skip to main content

View full-text article in PMC

. 2024 Feb 8;67(4):2849–2863. doi: 10.1021/acs.jmedchem.3c01976

Table 4. Antiparasitic Profile and Toxicity of 2, 31a, and 31c.

compound		pIC₅₀^a
	T. b. brucei	T. b. rhodesiense	T. cruzi	L. infantum	MRC-5	PMM
2	7.2 ± 0.2	N.D.	<4.2	<4.2	<4.2	<4.2
31a	8.0 ± 0.0	8.0 ± 0.0	<4.2	<4.2	<4.2	<4.2
31c	7.8 ± 0.0	8.0 ± 0.0	<4.2	<4.2	<4.2	<4.2

^a

Mean values ± standard deviations, n ≥ 2; PMM: peritoneal mouse macrophages.